Natural Sphingadienes Inhibit Akt-Dependent Signaling and Prevent Intestinal Tumorigenesis

Sphingolipid metabolites regulate cell proliferation, migration and stress responses. Alterations in sphingolipid metabolism have been proposed to contribute to carcinogenesis, cancer progression, and drug resistance. We identified a family of natural sphingolipids called sphingadienes and investiga...

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Bibliographic Details
Main Authors: Fyrst, Henrik, Oskouian, Babak, Bandhuvula, Padmavathi, Gong, Yaqiong, Byun, Hoe Sup, Bittman, Robert, Lee, Andrew R., Saba, Julie D.
Format: Artigo
Language:Inglês
Published: 2009
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2795098/
https://ncbi.nlm.nih.gov/pubmed/19934323
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-09-2341
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