Natural Sphingadienes Inhibit Akt-Dependent Signaling and Prevent Intestinal Tumorigenesis

Sphingolipid metabolites regulate cell proliferation, migration and stress responses. Alterations in sphingolipid metabolism have been proposed to contribute to carcinogenesis, cancer progression, and drug resistance. We identified a family of natural sphingolipids called sphingadienes and investiga...

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Bibliografiske detaljer
Main Authors: Fyrst, Henrik, Oskouian, Babak, Bandhuvula, Padmavathi, Gong, Yaqiong, Byun, Hoe Sup, Bittman, Robert, Lee, Andrew R., Saba, Julie D.
Format: Artigo
Sprog:Inglês
Udgivet: 2009
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2795098/
https://ncbi.nlm.nih.gov/pubmed/19934323
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-09-2341
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