Sphingadienes show therapeutic efficacy in neuroblastoma in vitro and in vivo by targeting the AKT signaling pathway

Neuroblastoma is a childhood malignancy that accounts for approximately 15% of childhood cancer deaths. Only 20–35% of children with metastatic neuroblastoma survive with standard therapy. Identification of more effective therapies is essential to improving the outcome of children with high-stage di...

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Publicado en:Invest New Drugs
Autores principales: Zhao, Piming, Aguilar, Ana E., Lee, Joanna Y., Paul, Lucy A., Suh, Jung H., Puri, Latika, Zhang, Meng, Beckstead, Jennifer, Witkowski, Andrzej, Ryan, Robert O., Saba, Julie D.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2018
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6047934/
https://ncbi.nlm.nih.gov/pubmed/29335887
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10637-017-0558-5
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