New Design of MHC Class II Tetramers to Accommodate Fundamental Principles of Antigen Presentation

Direct identification and isolation of antigen-specific T cells became possible with the development of “MHC tetramers”, based on fluorescent avidins displaying biotinylated peptide-MHC (pMHC) complexes. This approach, extensively used for MHC class I–restricted T cells, has met very limited success...

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Main Authors: Landais, Elise, Romagnoli, Pablo A., Corper, Adam L., Shires, John, Altman, John D., Wilson, Ian A., Garcia, K. Christopher, Teyton, Luc
Format: Artigo
Sprog:Inglês
Udgivet: 2009
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2795019/
https://ncbi.nlm.nih.gov/pubmed/19923463
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.0902493
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