Conditional Mutation of Pkd2 Causes Cystogenesis and Upregulates β-Catenin

Loss of polycystin-2 (PC2) in mice (Pkd2(−/−)) results in total body edema, focal hemorrhage, structural cardiac defects, abnormal left-right axis, hepatorenal and pancreatic cysts, and embryonic lethality. The molecular mechanisms by which loss of PC2 leads to these phenotypes remain unknown. We ge...

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Main Authors: Kim, Ingyu, Ding, Tianbing, Fu, Yulong, Li, Cunxi, Cui, Lan, Li, Ao, Lian, Peiwen, Liang, Dan, Wang, Dao W., Guo, Caiying, Ma, Jie, Zhao, Ping, Coffey, Robert J., Zhan, Qimin, Wu, Guanqing
Formato: Artigo
Idioma:Inglês
Publicado: American Society of Nephrology 2009
Assuntos:
Basic Research
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2794231/
https://ncbi.nlm.nih.gov/pubmed/19939939
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2009030271
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