Loss of Primary Cilia Upregulates Renal Hypertrophic Signaling and Promotes Cystogenesis

Primary cilia dysfunction alters renal tubular cell proliferation and differentiation and associates with accelerated cyst formation in polycystic kidney disease. However, the mechanism leading from primary ciliary dysfunction to renal cyst formation is unknown. We hypothesize that primary cilia pre...

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Detalhes bibliográficos
Main Authors: Bell, P. Darwin, Fitzgibbon, Wayne, Sas, Kelli, Stenbit, Antine E., Amria, May, Houston, Amber, Reichert, Ryan, Gilley, Sandra, Siegal, Gene P., Bissler, John, Bilgen, Mehmet, Chou, Peter Cheng-te, Guay-Woodford, Lisa, Yoder, Brad, Haycraft, Courtney J., Siroky, Brian
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Nephrology 2011
Assuntos:
Basic Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3083306/
https://ncbi.nlm.nih.gov/pubmed/21493775
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2010050526
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