Tulp3 regulates renal cystogenesis by trafficking of cystoproteins to cilia

Polycystic kidney disease proteins, polycystin-1 and polycystin-2, localize to primary cilia. Polycystin knockouts have severe cystogenesis compared to ciliary disruption, whereas simultaneous ciliary loss suppresses excessive cyst growth. These data suggest the presence of a cystogenic activator th...

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Publicado no:Curr Biol
Main Authors: Hwang, Sun-Hee, Somatilaka, Bandarigoda N., Badgandi, Hemant, Palicharla, Vivek Reddy, Walker, Rebecca, Shelton, John M., Qian, Feng, Mukhopadhyay, Saikat
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6401225/
https://ncbi.nlm.nih.gov/pubmed/30799239
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cub.2019.01.047
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