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Structures of Sortase B from Staphylococcus aureus and Bacillus anthracis Reveal Catalytic Amino Acid Triad in the Active Site

Surface proteins attached by sortases to the cell wall envelope of bacterial pathogens play important roles during infection. Sorting and attachment of these proteins is directed by C-terminal signals. Sortase B of S. aureus recognizes a motif NPQTN, cleaves the polypeptide after the Thr residue, an...

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Autors principals: Zhang, Rongguang, Wu, Ruiying, Joachimiak, Grazyna, Mazmanian, Sarkis K., Missiakas, Dominique M., Gornicki, Piotr, Schneewind, Olaf, Joachimiak, Andrzej
Format: Artigo
Idioma:Inglês
Publicat: 2004
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2792001/
https://ncbi.nlm.nih.gov/pubmed/15242591
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2004.06.001
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