Systemic administration of optimized aptamer-siRNA chimeras promotes regression of PSMA-expressing tumors

Prostate cancer cells expressing prostate-specific membrane antigen (PSMA) have been targeted with RNA aptamer–small interfering (si)RNA chimeras, but therapeutic efficacy in vivo was demonstrated only with intratumoral injection. Clinical translation of this approach will require chimeras that are...

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Bibliografiske detaljer
Main Authors: Dassie, Justin P, Liu, Xiu-ying, Thomas, Gregory S, Whitaker, Ryan M, Thiel, Kristina W, Stockdale, Katie R, Meyerholz, David K, McCaffrey, Anton P, McNamara, James O, Giangrande, Paloma H
Format: Artigo
Sprog:Inglês
Udgivet: 2009
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2791695/
https://ncbi.nlm.nih.gov/pubmed/19701187
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nbt.1560
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