Cell-Internalization SELEX: Method for Identifying Cell-Internalizing RNA Aptamers for Delivering siRNAs to Target Cells

After a decade of work to address cellular uptake, the principal obstacle to RNAi-based therapeutics, there is now well-deserved, renewed optimism about RNAi-based drugs. Phase I and II studies have shown safe, strong, and durable-gene knockdown (80–90 %, lasting for a month after a single injection...

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Xehetasun bibliografikoak
Argitaratua izan da:Methods Mol Biol
Egile Nagusiak: Thiel, William H., Thiel, Kristina W., Flenker, Katie S., Bair, Tom, Dupuy, Adam J., McNamara, James O., Miller, Francis J., Giangrande, Paloma H.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2015
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4435695/
https://ncbi.nlm.nih.gov/pubmed/25319652
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/978-1-4939-1538-5_11
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