EpCAM Aptamer-siRNA Chimera Targets and Regress Epithelial Cancer

Epithelial cell adhesion molecule (EpCAM), a cancer stem cell (CSC) marker is over expressed in epithelial cancers and in retinoblastoma (RB). We fabricated an EpCAM targeting aptamer-siRNA chimera and investigated its anti-tumor property and EpCAM intracellular domain (EpICD) mediated signaling in...

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Dades bibliogràfiques
Publicat a:PLoS One
Autors principals: Subramanian, Nithya, Kanwar, Jagat R., Kanwar, Rupinder K., Sreemanthula, JagadeeshBabu, Biswas, Jyotirmay, Khetan, Vikas, Krishnakumar, Subramanian
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2015
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4503753/
https://ncbi.nlm.nih.gov/pubmed/26176230
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0132407
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