EpCAM aptamer mediated cancer cell specific delivery of EpCAM siRNA using polymeric nanocomplex

BACKGROUND: Epithelial cell adhesion molecule (EpCAM) is overexpressed in solid tumors and regarded as a putative cancer stem cell marker. Here, we report that employing EpCAM aptamer (EpApt) and EpCAM siRNA (SiEp) dual approach, for the targeted delivery of siRNA to EpCAM positive cancer cells, eff...

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Dettagli Bibliografici
Pubblicato in:J Biomed Sci
Autori principali: Subramanian, Nithya, Kanwar, Jagat R, Athalya, Prasanna kumar, Janakiraman, Narayanan, Khetan, Vikas, Kanwar, Rupinder K, Eluchuri, Sailaja, Krishnakumar, Subramanian
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2015
Soggetti:
Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4307906/
https://ncbi.nlm.nih.gov/pubmed/25576037
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12929-014-0108-9
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