EpCAM aptamer mediated cancer cell specific delivery of EpCAM siRNA using polymeric nanocomplex

BACKGROUND: Epithelial cell adhesion molecule (EpCAM) is overexpressed in solid tumors and regarded as a putative cancer stem cell marker. Here, we report that employing EpCAM aptamer (EpApt) and EpCAM siRNA (SiEp) dual approach, for the targeted delivery of siRNA to EpCAM positive cancer cells, eff...

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Detalhes bibliográficos
Publicado no:J Biomed Sci
Main Authors: Subramanian, Nithya, Kanwar, Jagat R, Athalya, Prasanna kumar, Janakiraman, Narayanan, Khetan, Vikas, Kanwar, Rupinder K, Eluchuri, Sailaja, Krishnakumar, Subramanian
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2015
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4307906/
https://ncbi.nlm.nih.gov/pubmed/25576037
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12929-014-0108-9
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