EpCAM aptamer mediated cancer cell specific delivery of EpCAM siRNA using polymeric nanocomplex

BACKGROUND: Epithelial cell adhesion molecule (EpCAM) is overexpressed in solid tumors and regarded as a putative cancer stem cell marker. Here, we report that employing EpCAM aptamer (EpApt) and EpCAM siRNA (SiEp) dual approach, for the targeted delivery of siRNA to EpCAM positive cancer cells, eff...

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Bibliografiske detaljer
Udgivet i:J Biomed Sci
Main Authors: Subramanian, Nithya, Kanwar, Jagat R, Athalya, Prasanna kumar, Janakiraman, Narayanan, Khetan, Vikas, Kanwar, Rupinder K, Eluchuri, Sailaja, Krishnakumar, Subramanian
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2015
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4307906/
https://ncbi.nlm.nih.gov/pubmed/25576037
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12929-014-0108-9
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