Defective insulin secretion and enhanced insulin action in K(ATP) channel-deficient mice

ATP-sensitive K(+) (K(ATP)) channels regulate many cellular functions by linking cell metabolism to membrane potential. We have generated K(ATP) channel-deficient mice by genetic disruption of Kir6.2, which forms the K(+) ion-selective pore of the channel. The homozygous mice (Kir6.2(−/−)) lack K(AT...

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Библиографические подробности
Главные авторы: Miki, Takashi, Nagashima, Kazuaki, Tashiro, Fumi, Kotake, Kazumi, Yoshitomi, Hideyuki, Tamamoto, Atsuko, Gonoi, Tohru, Iwanaga, Toshihiko, Miyazaki, Jun-ichi, Seino, Susumu
Формат: Artigo
Язык:Inglês
Опубликовано: The National Academy of Sciences 1998
Предметы:
Biological Sciences
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC27906/
https://ncbi.nlm.nih.gov/pubmed/9724715
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