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A Cu-Catalyzed, pH-Neutral, Aerobic, Room Temperature Construction of High Enantiopurity Peptidyl Ketones from Peptidic S-Acylthiosalicylamides

[Image: see text] Described herein is a Cu-catalyzed transformation of peptidic thiol esters and boronic acids into peptidyl ketones that takes place at room temperature in DMF or in DMF/H(2)O open to air and uses only catalytic quantities of a Cu carboxylate to mediate the reaction. This aerobic tr...

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Bibliografiske detaljer
Main Authors: Liebeskind, Lanny S., Yang, Hao, Li, Hao
Format: Artigo
Sprog:Inglês
Udgivet: 2009
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2790066/
https://ncbi.nlm.nih.gov/pubmed/19145620
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.200804524
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