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Synthesis of High Enantiopurity N-Protected α-Amino Ketones by Thiol Ester-Organostannane Cross-Coupling using pH-Neutral Conditions
[Image: see text] An efficient synthesis of high enantiopurity N-protected α-amino ketones is described. Complementing other studies using boronic acids and thiol esters, this Cu(I) diphenylphosphinate (CuDPP)-mediated, palladium-catalyzed coupling of α-amino thiol esters with aryl, heteroaryl, ally...
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| Autores principales: | , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2008
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2654251/ https://ncbi.nlm.nih.gov/pubmed/18759432 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ol8018456 |
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