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A Concise and Scalable Synthesis of High Enantiopurity (−)-D-erythro-Sphingosine Using Peptidyl Thiol Ester-Boronic Acid Cross-Coupling

[Image: see text] A short and efficient synthesis of high enantiopurity (−)-D-erythro-sphingosine has been achieved in 71% yield over 6 steps from N-Boc-L-serine. The key steps are high yield, racemization-free, palladium-catalyzed, copper(I)-mediated coupling of the thiophenyl ester of N-Boc-O-TBS...

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Autores principales: Yang, Hao, Liebeskind, Lanny S.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2007
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2663357/
https://ncbi.nlm.nih.gov/pubmed/17608484
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ol070991m
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