Lack of periostin leads to suppression of Notch1 signaling and calcific aortic valve disease

The Postn gene encodes protein periostin. During embryonic development, it is highly expressed in the outflow tract (OFT) endocardial cushions of the developing heart, which give rise to several structures of the mature heart including the aortic valve. Periostin was previously implicated in osteobl...

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Hlavní autoři: Tkatchenko, Tatiana V., Moreno-Rodriguez, Ricardo A., Conway, Simon J., Molkentin, Jeffery D., Markwald, Roger R., Tkatchenko, Andrei V.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Physiological Society 2009
Témata:
Translational Physiology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2789674/
https://ncbi.nlm.nih.gov/pubmed/19723774
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/physiolgenomics.00078.2009
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