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Probing the Role of Backbone Hydrogen Bonding in a Critical β-sheet of the Extracellular Domain of a Cys-loop Receptor

Long-range communication is essential for the function of members of the Cys-loop family of neurotransmitter-gated ion channels. The involvement of the peptide backbone in binding-induced conformational changes that lead to channel gating in these membrane proteins is an interesting, but unresolved...

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Main Authors: Gleitsman, Kristin R., Lester, Henry A., Dougherty, Dennis A.
Format: Artigo
Sprog:Inglês
Udgivet: 2009
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2789490/
https://ncbi.nlm.nih.gov/pubmed/19405066
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cbic.200900092
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