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Voltage-Dependent Modulation of Cardiac Ryanodine Receptors (RyR2) by Protamine

It has been reported that protamine (>10 µg/ml) blocks single skeletal RyR1 channels and inhibits RyR1-mediated Ca(2+) release from sarcoplasmic reticulum microsomes. We extended these studies to cardiac RyR2 reconstituted into planar lipid bilayers. We found that protamine (0.02–20 µg/ml) added...

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Hlavní autoři: Diaz-Sylvester, Paula L., Copello, Julio A.
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2009
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2789381/
https://ncbi.nlm.nih.gov/pubmed/20016815
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0008315
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