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Electrostatic Mechanisms Underlie Neomycin Block of the Cardiac Ryanodine Receptor Channel (RyR2)

Neomycin is a large, positively charged, aminoglycoside antibiotic that has previously been shown to induce a voltage-dependent substate block in the cardiac isoform of the ryanodine receptor (RyR2). It was proposed that block involved an electrostatic interaction between neomycin and putative regio...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Mead, Fiona C., Williams, Alan J.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Biophysical Society 2004
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC1304893/
https://ncbi.nlm.nih.gov/pubmed/15361409
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.104.049338
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