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Electrostatic Mechanisms Underlie Neomycin Block of the Cardiac Ryanodine Receptor Channel (RyR2)

Neomycin is a large, positively charged, aminoglycoside antibiotic that has previously been shown to induce a voltage-dependent substate block in the cardiac isoform of the ryanodine receptor (RyR2). It was proposed that block involved an electrostatic interaction between neomycin and putative regio...

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Detalhes bibliográficos
Main Authors: Mead, Fiona C., Williams, Alan J.
Formato: Artigo
Idioma:Inglês
Publicado em: Biophysical Society 2004
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1304893/
https://ncbi.nlm.nih.gov/pubmed/15361409
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.104.049338
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