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Electrostatic Mechanisms Underlie Neomycin Block of the Cardiac Ryanodine Receptor Channel (RyR2)
Neomycin is a large, positively charged, aminoglycoside antibiotic that has previously been shown to induce a voltage-dependent substate block in the cardiac isoform of the ryanodine receptor (RyR2). It was proposed that block involved an electrostatic interaction between neomycin and putative regio...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Biophysical Society
2004
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| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1304893/ https://ncbi.nlm.nih.gov/pubmed/15361409 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.104.049338 |
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