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Changes in Negative Charge at the Luminal Mouth of the Pore Alter Ion Handling and Gating in the Cardiac Ryanodine-Receptor
We have tested the hypothesis that a high density of negative charge at the luminal mouth of the RyR2 pore plays a pivotal role in the high cation conductance and limited selectivity observed in this channel by introducing into each monomer a double point mutation to neutralize acidic residues in th...
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Autores principales: | , , , , , |
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Formato: | Artigo |
Lenguaje: | Inglês |
Publicado: |
The Biophysical Society
2009
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Materias: | |
Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2717239/ https://ncbi.nlm.nih.gov/pubmed/19217855 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2008.10.054 |
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