Changes in Negative Charge at the Luminal Mouth of the Pore Alter Ion Handling and Gating in the Cardiac Ryanodine-Receptor

We have tested the hypothesis that a high density of negative charge at the luminal mouth of the RyR2 pore plays a pivotal role in the high cation conductance and limited selectivity observed in this channel by introducing into each monomer a double point mutation to neutralize acidic residues in th...

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Библиографические подробности
Главные авторы: Mead-Savery, Fiona C., Wang, Ruiwu, Tanna-Topan, Bhavna, Chen, S.R. Wayne, Welch, William, Williams, Alan J.
Формат: Artigo
Язык:Inglês
Опубликовано: The Biophysical Society 2009
Предметы:
Channels, Receptors, and Electrical Signaling
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2717239/
https://ncbi.nlm.nih.gov/pubmed/19217855
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2008.10.054
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