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Voltage-Dependent Modulation of Cardiac Ryanodine Receptors (RyR2) by Protamine
It has been reported that protamine (>10 µg/ml) blocks single skeletal RyR1 channels and inhibits RyR1-mediated Ca(2+) release from sarcoplasmic reticulum microsomes. We extended these studies to cardiac RyR2 reconstituted into planar lipid bilayers. We found that protamine (0.02–20 µg/ml) added...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2789381/ https://ncbi.nlm.nih.gov/pubmed/20016815 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0008315 |
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