Oxygen-Regulated β(2)-Adrenergic Receptor Hydroxylation by EGLN3 and Ubiquitylation by pVHL

Agonist-induced ubiquitylation and degradation of heterotrimeric guanine nucleotide–binding protein (G protein)–coupled receptors (GPCRs) play an essential role in surface receptor homeostasis, thereby tuning many physiological processes. Although β-arrestin and affiliated E3 ligases mediate agonist...

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Bibliographic Details
Main Authors: Xie, Liang, Xiao, Kunhong, Whalen, Erin J., Forrester, Michael T., Freeman, Robert S., Fong, Guohua, Gygi, Steven P., Lefkowitz, Robert J., Stamler, Jonathan S.
Format: Artigo
Language:Inglês
Published: 2009
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2788937/
https://ncbi.nlm.nih.gov/pubmed/19584355
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.2000444
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