iTRAQ Proteomic identification of pVHL-dependent and -independent targets of Egln1 prolyl hydroxylase knockdown in renal carcinoma cells

The large subunit of RNA Polymerase II, Rpb1, undergoes hydroxylation on proline 1465, which in turn triggers Ser5 hydroxylation. While Egln2 prolyl hydroxylase appears to mediate P1465 hydroxylation, Egln1 has an inhibitory activity and its knockdown stimulates constitutive hydroxylation and Ser5 p...

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Главные авторы: Haffey, Wendy D., Mikhaylova, Olga, Meller, Jarek, Yi, Ying, Greis, Kenneth D., Czyzyk-Krzeska, Maria F.
Формат: Artigo
Язык:Inglês
Опубликовано: 2008
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2716563/
https://ncbi.nlm.nih.gov/pubmed/19159641
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.advenzreg.2008.12.004
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