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VHL-dependent patterns of RNA polymerase II hydroxylation in human renal clear cell carcinomas
PURPOSE: We have previously shown that VHL regulates ubiquitylation and Proline P1465 hydroxylation of the large subunit of RNA polymerase II, Rpb1, in human RCC cell lines. Here, our goal was to determine the impact of this VHL function and the status of P1465 hydroxylation in human RCC tumors. EXP...
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| Hauptverfasser: | , , , , , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2010
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2970636/ https://ncbi.nlm.nih.gov/pubmed/20978146 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-09-3416 |
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