VHL-regulated miR-204 Suppresses Tumor Growth through Inhibition of LC3B-mediated Autophagy in Renal Clear Cell Carcinoma

The von Hippel-Lindau tumor-suppressor gene (VHL) is lost in most clear cell renal cell carcinomas (ccRCC). Here, using human ccRCC specimens, VHL-deficient cells, and xenograft models, we show that miR-204 is a VHL-regulated tumor suppressor acting by inhibiting macroautophagy, with MAP1LC3B (LC3B)...

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Detalhes bibliográficos
Main Authors: Mikhaylova, Olga, Stratton, Yiwen, Hall, Daniel, Kellner, Emily, Ehmer, Birgit, Drew, Angela F., Gallo, Catherine A., Plas, David R., Biesiada, Jacek, Meller, Jarek, Czyzyk-Krzeska, Maria F.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3331999/
https://ncbi.nlm.nih.gov/pubmed/22516261
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2012.02.019
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