TRPM3 and miR-204 establish a regulatory circuit that controls oncogenic autophagy in clear cell renal cell carcinoma

Autophagy promotes tumor growth by generating nutrients from the degradation of intracellular structures. Here we establish, using shRNAs, a dominant negative mutant, and a pharmacologic inhibitor, mefenamic acid (MFA), that the Transient Receptor Potential Melastatin 3 (TRPM3) channel promotes grow...

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Bibliographic Details
Published in:Cancer Cell
Main Authors: Hall, Daniel P., Cost, Nicholas G., Hegde, Shailaja, Kellner, Emily, Mikhaylova, Olga, Stratton, Yiwen, Ehmer, Birgit, Abplanalp, William A., Pandey, Raghav, Biesiada, Jacek, Harteneck, Christian, Plas, David R., Meller, Jarek, Czyzyk-Krzeska, Maria F.
Format: Artigo
Language:Inglês
Published: 2014
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4269832/
https://ncbi.nlm.nih.gov/pubmed/25517751
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2014.09.015
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