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Characterization of a novel novobiocin analogue as a putative C-terminal inhibitor of heat shock protein 90 in prostate cancer cells

PURPOSE: Hsp90 is important in the folding, maturation and stabilization of pro-tumorigenic client proteins and represents a viable drug target for the design of chemotherapies. Previously, we reported the development of novobiocin analogues designed to inhibit the C-terminal portion of Hsp90, which...

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Bibliografiske detaljer
Main Authors: Shawna, B. Comer, George, A. Vielhauer, Craig, A. Manthe, Vamsee, K. Chaguturu, Kristen, Szabla, Robert, L. Matts, Alison, C. Donnelly, Brian, S. J. Blagg, Jeffrey, M. Holzbeierlein
Format: Artigo
Sprog:Inglês
Udgivet: 2010
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2787716/
https://ncbi.nlm.nih.gov/pubmed/19739131
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pros.21035
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