KU135, a Novel Novobiocin-Derived C-Terminal Inhibitor of the 90-kDa Heat Shock Protein, Exerts Potent Antiproliferative Effects in Human Leukemic Cells

The 90-kDa heat shock protein (Hsp90) assists in the proper folding of numerous mutated or overexpressed signal transduction proteins that are involved in cancer. Consequently, there is considerable interest in developing chemotherapeutic drugs that specifically disrupt the function of Hsp90. Here,...

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Main Authors: Shelton, Shary N., Shawgo, Mary E., Matthews, Shawna B., Lu, Yuanming, Donnelly, Alison C., Szabla, Kristen, Tanol, Mehmet, Vielhauer, George A., Rajewski, Roger A., Matts, Robert L., Blagg, Brian S. J., Robertson, John D.
Formato: Artigo
Idioma:Inglês
Publicado: The American Society for Pharmacology and Experimental Therapeutics 2009
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Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2784729/
https://ncbi.nlm.nih.gov/pubmed/19741006
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.109.058545
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