Suboptimal Activation of Protease-activated Receptors Enhances α(2)β(1) Integrin-mediated Platelet Adhesion to Collagen

Thrombin and fibrillar collagen are potent activators of platelets at sites of vascular injury. Both agonists cause platelet shape change, granule secretion, and aggregation to form the primary hemostatic plug. Human platelets express two thrombin receptors, protease-activated receptors 1 and 4 (PAR...

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Hlavní autoři: Marjoram, Robin J., Voss, Bryan, Pan, Yumei, Dickeson, S. Kent, Zutter, Mary M., Hamm, Heidi E., Santoro, Samuel A.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2009
Témata:
Glycobiology and Extracellular Matrices
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2787326/
https://ncbi.nlm.nih.gov/pubmed/19815553
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.020990
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