Suboptimal Activation of Protease-activated Receptors Enhances α(2)β(1) Integrin-mediated Platelet Adhesion to Collagen

Thrombin and fibrillar collagen are potent activators of platelets at sites of vascular injury. Both agonists cause platelet shape change, granule secretion, and aggregation to form the primary hemostatic plug. Human platelets express two thrombin receptors, protease-activated receptors 1 and 4 (PAR...

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Bibliografiske detaljer
Main Authors: Marjoram, Robin J., Voss, Bryan, Pan, Yumei, Dickeson, S. Kent, Zutter, Mary M., Hamm, Heidi E., Santoro, Samuel A.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2009
Fag:
Glycobiology and Extracellular Matrices
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2787326/
https://ncbi.nlm.nih.gov/pubmed/19815553
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.020990
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