Enhancing Integrin α1 Inserted (I) Domain Affinity to Ligand Potentiates Integrin α1β1-mediated Down-regulation of Collagen Synthesis

Integrin α1β1 binding to collagen IV, which is mediated by the α1-inserted (I) domain, down-regulates collagen synthesis. When unligated, a salt bridge between Arg(287) and Glu(317) is thought to keep this domain in a low affinity conformation. Ligand binding opens the salt bridge leading to a high-...

Description complète

Enregistré dans:
Détails bibliographiques
Auteurs principaux: Shi, Mingjian, Pedchenko, Vadim, Greer, Briana H., Van Horn, Wade D., Santoro, Samuel A., Sanders, Charles R., Hudson, Billy G., Eichman, Brandt F., Zent, Roy, Pozzi, Ambra
Format: Artigo
Langue:Inglês
Publié: American Society for Biochemistry and Molecular Biology 2012
Sujets:
Glycobiology and Extracellular Matrices
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3471707/
https://ncbi.nlm.nih.gov/pubmed/22888006
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.358648
Tags: Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!

Documents similaires