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Salt-bridge modulates differential calcium-mediated ligand binding to integrin α1- and α2-I domains
Integrins are transmembrane cell-extracellular matrix adhesion receptors that impact many cellular functions. A subgroup of integrins contain an inserted (I) domain within the α–subunits (αI) that mediate ligand recognition where function is contingent on binding a divalent cation at the metal ion d...
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| Publicado no: | Sci Rep |
|---|---|
| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5811549/ https://ncbi.nlm.nih.gov/pubmed/29440721 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-21231-1 |
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