Salt-bridge modulates differential calcium-mediated ligand binding to integrin α1- and α2-I domains

Integrins are transmembrane cell-extracellular matrix adhesion receptors that impact many cellular functions. A subgroup of integrins contain an inserted (I) domain within the α–subunits (αI) that mediate ligand recognition where function is contingent on binding a divalent cation at the metal ion d...

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Udgivet i:Sci Rep
Main Authors: Brown, Kyle L., Banerjee, Surajit, Feigley, Andrew, Abe, Hanna, Blackwell, Timothy S., Pozzi, Ambra, Hudson, Billy G., Zent, Roy
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5811549/
https://ncbi.nlm.nih.gov/pubmed/29440721
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-21231-1
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