Enhancing Integrin α1 Inserted (I) Domain Affinity to Ligand Potentiates Integrin α1β1-mediated Down-regulation of Collagen Synthesis

Integrin α1β1 binding to collagen IV, which is mediated by the α1-inserted (I) domain, down-regulates collagen synthesis. When unligated, a salt bridge between Arg(287) and Glu(317) is thought to keep this domain in a low affinity conformation. Ligand binding opens the salt bridge leading to a high-...

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Bibliographische Detailangaben
Hauptverfasser: Shi, Mingjian, Pedchenko, Vadim, Greer, Briana H., Van Horn, Wade D., Santoro, Samuel A., Sanders, Charles R., Hudson, Billy G., Eichman, Brandt F., Zent, Roy, Pozzi, Ambra
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2012
Schlagworte:
Glycobiology and Extracellular Matrices
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3471707/
https://ncbi.nlm.nih.gov/pubmed/22888006
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.358648
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