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Magnitude of a Conformational Change in the Glycine Receptor β1-β2 Loop Is Correlated with Agonist Efficacy

The efficacy of agonists at Cys-loop ion channel receptors is determined by the rate they isomerize receptors to a pre-open flip state. Once the flip state is reached, the shut-open reaction is similar for low and high efficacy agonists. The present study sought to identify a conformational change a...

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Main Authors: Pless, Stephan A., Lynch, Joseph W.
格式: Artigo
語言:Inglês
出版: American Society for Biochemistry and Molecular Biology 2009
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2785665/
https://ncbi.nlm.nih.gov/pubmed/19643731
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.048405
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