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β Subunit M2–M3 Loop Conformational Changes Are Uncoupled from α1 β Glycine Receptor Channel Gating: Implications for Human Hereditary Hyperekplexia

Hereditary hyperekplexia, or startle disease, is a neuromotor disorder caused mainly by mutations that either prevent the surface expression of, or modify the function of, the human heteromeric α1 β glycine receptor (GlyR) chloride channel. There is as yet no explanation as to why hyperekplexia muta...

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Bibliografiska uppgifter
Huvudupphovsmän: Shan, Qiang, Han, Lu, Lynch, Joseph W.
Materialtyp: Artigo
Språk:Inglês
Publicerad: Public Library of Science 2011
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3222680/
https://ncbi.nlm.nih.gov/pubmed/22132222
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0028105
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