Ischemia Activates the ATF6 Branch of the Endoplasmic Reticulum Stress Response

Stresses that perturb the folding of nascent endoplasmic reticulum (ER) proteins activate the ER stress response. Upon ER stress, ER-associated ATF6 is cleaved; the resulting active cytosolic fragment of ATF6 translocates to the nucleus, binds to ER stress response elements (ERSEs), and induces gene...

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Bibliographic Details
Main Authors: Doroudgar, Shirin, Thuerauf, Donna J., Marcinko, Marie C., Belmont, Peter J., Glembotski, Christopher C.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2009
Subjects:
Protein Synthesis, Post-Translational Modification, and Degradation
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2785605/
https://ncbi.nlm.nih.gov/pubmed/19622751
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.018036
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