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Detailed Mechanistic Insights into HIV-1 Sensitivity to Three Generations of Fusion Inhibitors
Peptides based on the second heptad repeat (HR2) of viral class I fusion proteins are effective inhibitors of virus entry. One such fusion inhibitor has been approved for treatment of human immunodeficiency virus-1 (T20, enfuvirtide). Resistance to T20 usually maps to the peptide binding site in HR1...
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Asıl Yazarlar: | , , , , , , |
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Materyal Türü: | Artigo |
Dil: | Inglês |
Baskı/Yayın Bilgisi: |
American Society for Biochemistry and Molecular Biology
2009
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Konular: | |
Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2785381/ https://ncbi.nlm.nih.gov/pubmed/19617355 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.004416 |
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