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Detailed Mechanistic Insights into HIV-1 Sensitivity to Three Generations of Fusion Inhibitors

Peptides based on the second heptad repeat (HR2) of viral class I fusion proteins are effective inhibitors of virus entry. One such fusion inhibitor has been approved for treatment of human immunodeficiency virus-1 (T20, enfuvirtide). Resistance to T20 usually maps to the peptide binding site in HR1...

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Detaylı Bibliyografya
Asıl Yazarlar: Eggink, Dirk, Langedijk, Johannes P. M., Bonvin, Alexandre M. J. J., Deng, Yiqun, Lu, Min, Berkhout, Ben, Sanders, Rogier W.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Biochemistry and Molecular Biology 2009
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2785381/
https://ncbi.nlm.nih.gov/pubmed/19617355
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.004416
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