Exogenous α-synuclein fibrils seed the formation of Lewy body-like intracellular inclusions in cultured cells

Cytoplasmic inclusions containing α-synuclein (α-Syn) fibrils, referred to as Lewy bodies (LBs), are the signature neuropathological hallmarks of Parkinson's disease (PD). Although α-Syn fibrils can be generated from recombinant α-Syn protein in vitro, the production of fibrillar α-Syn inclusio...

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Hlavní autoři: Luk, Kelvin C., Song, Cheng, O'Brien, Patrick, Stieber, Anna, Branch, Jonathan R., Brunden, Kurt R., Trojanowski, John Q., Lee, Virginia M.-Y.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2009
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2785290/
https://ncbi.nlm.nih.gov/pubmed/19892735
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0908005106
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