Modeling Parkinson’s disease pathology by combination of fibril seeds and α-synuclein overexpression in the rat brain

Although a causative role of α-synuclein (α-syn) is well established in Parkinson’s disease pathogenesis, available animal models of synucleinopathy do not replicate the full range of cellular and behavioral changes characteristic of the human disease. This study was designed to generate a more fait...

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Dettagli Bibliografici
Pubblicato in:Proc Natl Acad Sci U S A
Autori principali: Thakur, Poonam, Breger, Ludivine S., Lundblad, Martin, Wan, Oi Wan, Mattsson, Bengt, Luk, Kelvin C., Lee, Virginia M. Y., Trojanowski, John Q., Björklund, Anders
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2017
Soggetti:
PNAS Plus
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5625925/
https://ncbi.nlm.nih.gov/pubmed/28900002
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1710442114
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