Modeling Parkinson’s disease pathology by combination of fibril seeds and α-synuclein overexpression in the rat brain

Although a causative role of α-synuclein (α-syn) is well established in Parkinson’s disease pathogenesis, available animal models of synucleinopathy do not replicate the full range of cellular and behavioral changes characteristic of the human disease. This study was designed to generate a more fait...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Thakur, Poonam, Breger, Ludivine S., Lundblad, Martin, Wan, Oi Wan, Mattsson, Bengt, Luk, Kelvin C., Lee, Virginia M. Y., Trojanowski, John Q., Björklund, Anders
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2017
Assuntos:
PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5625925/
https://ncbi.nlm.nih.gov/pubmed/28900002
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1710442114
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