Impact of α-synuclein pathology on transplanted hESC-derived dopaminergic neurons in a humanized α-synuclein rat model of PD

Preclinical assessment of the therapeutic potential of dopamine (DA) neuron replacement in Parkinson’s disease (PD) has primarily been performed in the 6-hydroxydopamine toxin model. While this is a good model to assess graft function, it does not reflect the pathological features or progressive nat...

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Bibliografiska uppgifter
I publikationen:Proc Natl Acad Sci U S A
Huvudupphovsmän: Hoban, Deirdre B., Shrigley, Shelby, Mattsson, Bengt, Breger, Ludivine S., Jarl, Ulla, Cardoso, Tiago, Nelander Wahlestedt, Jenny, Luk, Kelvin C., Björklund, Anders, Parmar, Malin
Materialtyp: Artigo
Språk:Inglês
Publicerad: National Academy of Sciences 2020
Ämnen:
Biological Sciences
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC7334514/
https://ncbi.nlm.nih.gov/pubmed/32541058
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2001305117
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