Grafts Derived from an α-Synuclein Triplication Patient Mediate Functional Recovery but Develop Disease-Associated Pathology in the 6-OHDA Model of Parkinson’s Disease

BACKGROUND: Human induced pluripotent stem cells (hiPSCs) have been proposed as an alternative source for cell replacement therapy for Parkinson’s disease (PD) and they provide the option of using the patient’s own cells. A few studies have investigated transplantation of patient-derived dopaminergi...

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Bibliografiske detaljer
Udgivet i:J Parkinsons Dis
Main Authors: Shrigley, Shelby, Nilsson, Fredrik, Mattsson, Bengt, Fiorenzano, Alessandro, Mudannayake, Janitha, Bruzelius, Andreas, Ottosson, Daniella Rylander, Björklund, Anders, Hoban, Deirdre B., Parmar, Malin
Format: Artigo
Sprog:Inglês
Udgivet: IOS Press 2021
Fag:
Research Report
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8150478/
https://ncbi.nlm.nih.gov/pubmed/33361611
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3233/JPD-202366
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