Grafts Derived from an α-Synuclein Triplication Patient Mediate Functional Recovery but Develop Disease-Associated Pathology in the 6-OHDA Model of Parkinson’s Disease

BACKGROUND: Human induced pluripotent stem cells (hiPSCs) have been proposed as an alternative source for cell replacement therapy for Parkinson’s disease (PD) and they provide the option of using the patient’s own cells. A few studies have investigated transplantation of patient-derived dopaminergi...

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Dades bibliogràfiques
Publicat a:J Parkinsons Dis
Autors principals: Shrigley, Shelby, Nilsson, Fredrik, Mattsson, Bengt, Fiorenzano, Alessandro, Mudannayake, Janitha, Bruzelius, Andreas, Ottosson, Daniella Rylander, Björklund, Anders, Hoban, Deirdre B., Parmar, Malin
Format: Artigo
Idioma:Inglês
Publicat: IOS Press 2021
Matèries:
Research Report
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8150478/
https://ncbi.nlm.nih.gov/pubmed/33361611
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3233/JPD-202366
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