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TFEB-mediated autophagy rescues midbrain dopamine neurons from α-synuclein toxicity
The aggregation of α-synuclein plays a major role in Parkinson disease (PD) pathogenesis. Recent evidence suggests that defects in the autophagy-mediated clearance of α-synuclein contribute to the progressive loss of nigral dopamine neurons. Using an in vivo model of α-synuclein toxicity, we show th...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3651458/ https://ncbi.nlm.nih.gov/pubmed/23610405 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1305623110 |
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