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Reconstitution of Human Claspin-mediated Phosphorylation of Chk1 by the ATR (Ataxia Telangiectasia-mutated and Rad3-related) Checkpoint Kinase

ATR (ATM and Rad3-related) initiates a DNA damage signaling pathway in human cells upon DNA damage induced by UV and UV-mimetic agents and in response to inhibition of DNA replication. Genetic data with human cells and in vitro data with Xenopus egg extracts have led to the conclusion that the kinas...

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Bibliografske podrobnosti
Main Authors: Lindsey-Boltz, Laura A., Serçin, Özdemirhan, Choi, Jun-Hyuk, Sancar, Aziz
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2009
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2785152/
https://ncbi.nlm.nih.gov/pubmed/19828454
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.064485
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