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“Reverse Fleximers”: Introduction of a series of 5-substituted carbocyclic uridine analogues

Nucleosides are ubiquitous in biological systems and as such, have been a focus of medicinal chemistry research in the search for new and potent therapeutic compounds. There are a number of modified nucleosides on the market, however increasing reports of resistance by mutation of either the enzyme...

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Detalhes bibliográficos
Main Authors: Sadler, Joshua M., Ojewoye, Olubukola, Seley-Radtke, Katherine L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2785025/
https://ncbi.nlm.nih.gov/pubmed/18776508
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nass/nrn289
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