Design, synthesis and evaluation of a series of acyclic fleximer nucleoside analogues with anti-coronavirus activity

A series of doubly flexible nucleoside analogues were designed based on the acyclic sugar scaffold of acyclovir and the flex-base moiety found in the fleximers. The target compounds were evaluated for their antiviral potential and found to inhibit several coronaviruses. Significantly, compound 2 dis...

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Detaylı Bibliyografya
Yayımlandı:Bioorg Med Chem Lett
Asıl Yazarlar: Peters, Hannah L., Jochmans, Dirk, de Wilde, Adriaan H., Posthuma, Clara C., Snijder, Eric J., Neyts, Johan, Seley-Radtke, Katherine L.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Elsevier Ltd. 2015
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4466200/
https://ncbi.nlm.nih.gov/pubmed/26048809
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2015.05.039
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