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An Expedient Synthesis of Flexible Nucleosides through Enzymatic Glycosylation of Proximal and Distal Fleximer Bases

The structurally unique “fleximer” nucleosides were originally designed to investigate how flexibility in a nucleobase could potentially affect receptor–ligand recognition and function. Recently they have been shown to have low‐to‐sub‐micromolar levels of activity against a number of viruses, includ...

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Publicat a:Chembiochem
Autors principals: Vichier‐Guerre, Sophie, Ku, Therese C., Pochet, Sylvie, Seley‐Radtke, Katherine L.
Format: Artigo
Idioma:Inglês
Publicat: John Wiley and Sons Inc. 2020
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7228337/
https://ncbi.nlm.nih.gov/pubmed/31899839
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cbic.201900714
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